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Predictions of fluconazole inhibition on siponimod pharmacokinetics using  SimCYP   ADME simulator  version 9 (i, ii, iii) or version 16 (iv) and comparison with observed in vivo results

Journal: European Journal of Clinical Pharmacology

Article Title: In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics

doi: 10.1007/s00228-017-2404-2

Figure Lengend Snippet: Predictions of fluconazole inhibition on siponimod pharmacokinetics using SimCYP ADME simulator version 9 (i, ii, iii) or version 16 (iv) and comparison with observed in vivo results

Article Snippet: Simulation methods such as the SimCYP (SimCYP Ltd., Sheffield, UK) population-based ADME simulator help better understand the mechanisms that determine siponimod disposition in vivo.

Techniques: Inhibition, In Vivo